Assessment of Complete Blood Count of Sickle Cell Anemia Patients Attending Some Hospitals in Khartoum State

Abstract

This is case control study, conducted in some Khart oum State Hospitals during the period from March 2014 to May 2014. This study aimed to determine the complete blood count and frequency of sickle cell anemia among patients in some Khartoum State Hospitals. Two hundred (200) blood samples were collected, one hundred fifty for sicklers and fifty for apparently healthy individua ls as control. A questionnaire was designed to collect information a bout the study, 3ml of venous blood was collected in EDTA anticoagulant co ntainer and Automated Hematological Analyzer -Sysmex KX 21N- wa s used to investigate the hematological parameters. Blood sam ple was washed for preparing it for hemoglobin electrophoresis. total erythrocyte count, hemoglobin level, packed c ell volume and mean cell volume of the sickle cell anemia patients were (7.6± 2.1 g/dl ), (2.8± 0.9 × 10 12 /l), (23± 6.6 %) and (84±11.6 fl), respectively, wa s significantly decreased when compared with normal individual. No significant differences in sickle cell anemia pa tients in mean cell hemoglobin concentration (32±2.6%), mean cell hemog lobin (28 ±6.2pg) and platelet (330.5±142×10 3 /mm 3 ), (P < 0.47, P < 0.07, P<0.13) respectively when compared with normal individuals. The total leucocyte ( 15 .6±10.3 × 10 9 /l) (P < 0.00) was significantly elevated in sickle cell anemia when compared with normal ind ividual. The mean age of the sickle cell anemia patients was (5.2 year). The results showed that percentage of sickle cell trait and sickle cell disease were (25.5%) and (49.5%) respectively. According to social data inter-marriage played an i mportant role in spreading of sickle cell anemia and sickle cell ane mia is more common in Meseria and Bargo tribes.