Abstract:
This is case control study, conducted in some Khart
oum State Hospitals
during the period from March 2014 to May 2014. This
study aimed to
determine the complete blood count and frequency of
sickle cell anemia
among patients in some Khartoum State Hospitals.
Two hundred (200) blood samples were collected, one
hundred fifty for
sicklers and fifty for apparently healthy individua
ls as control. A
questionnaire was designed to collect information a
bout the study, 3ml of
venous blood was collected in EDTA anticoagulant co
ntainer and
Automated Hematological Analyzer -Sysmex KX 21N- wa
s used to
investigate the hematological parameters. Blood sam
ple was washed for
preparing it for hemoglobin electrophoresis.
total erythrocyte count, hemoglobin level, packed c
ell volume and mean
cell volume of the sickle cell anemia patients were
(7.6± 2.1 g/dl ), (2.8±
0.9
×
10
12
/l), (23± 6.6 %) and (84±11.6 fl), respectively, wa
s significantly
decreased when compared with normal individual.
No significant differences in sickle cell anemia pa
tients in mean cell
hemoglobin concentration (32±2.6%), mean cell hemog
lobin (28 ±6.2pg)
and platelet (330.5±142×10
3
/mm
3
), (P
<
0.47, P
<
0.07, P<0.13)
respectively when compared with normal individuals.
The total leucocyte (
15
.6±10.3
×
10
9
/l) (P
<
0.00) was significantly elevated
in sickle cell anemia when compared with normal ind
ividual.
The mean age of the sickle cell anemia patients was
(5.2 year). The
results showed that percentage of sickle cell trait
and sickle cell disease
were (25.5%) and (49.5%) respectively.
According to social data inter-marriage played an i
mportant role in
spreading of sickle cell anemia and sickle cell ane
mia is more common in
Meseria and Bargo tribes.
