Invitro Antifungal Activity Screening Test of Extracted Parts of Citrullus colocynthis on Pathogenic Dermatophytes Clinical Isolates

Abstract

This analytical study was conducted at the Department of Medical Microbiology, Sudan University of Science and Technology. During the period from April to September, 2012.The aim of the project was to detect antifungal activity of Citrullus colocynthis fruits and seeds extract against clinical dermatophytes isolates as well as standard fungi. The fruits and seeds were extracted using standard method and then their effect on dermatophytes was detected by using the cup diffusion method and controlled with standard strains, the used concentration was 10%. This study revealed that the Citrullus colocynthis fruits and seeds extracts produced prominent in vitro antifungal activity against all used fungal species, and the antifungal activity of fruits extract was more stronger than antifungal activity of seeds extract. And in addition these results showed the possibility of using this plant extracts in treatment of diseases caused by these pathogens, but further studies are required to detect a suitable concentration and dose, and screen other parts of this plant.