Evaluation of Plasma Lipid Profile Among Women Using Combined Oral Contraceptive Pills in Gazira State

Abstract

Background: Combined oral contraceptives pills are the most popular contraceptive method world-wide.50-60 % of women of reproductive age worldwide use this method for birth control. Dyslipidemia occurs in long tern oral contraceptives user women. Objective: This study was aimed to evaluate lipid profile among women using combined oral contraceptive pills in Gazira state. Materials and methods: This was cross sectional study concluded sample were collected using questionnaire the study conducted in Gazira state Total number of 40 women which using oral contraceptive conducted as case group and 40 of them not using oral contraceptive as control group ¸ fasting blood sample were collected for the estimation of lipid profile (cholesterol¸ triglycride ¸HDL¸LDL)the sample prepaired and spectrophotometrically measured · Result: analyzed result by using SPSS computer program version 22.0 with T test and P value was obtained (P value ≤ 0.05 was considered statistically significant. the mean of age in combined oral contraceptive group was (26.97± 6.21), the mean of height in combined oral contraceptive group was (160.2 ± 7.99), the mean of weight among case group was (88.8 ± 9.9) and mean of BMI was (34.3 ±3.32) among case group while (27.3 ± 8.1) among control group(P.value was (0.003 )considered significant different,the mean of serum total cholesterol in combined oral contraceptive group was (224.2 ± 26.7 mg/dL) and (183.0 ± 19.2 mg/dL) among control group .P.value was (0.028 ) considered significant different ,the mean of serum triglyceride in combined oral contraceptive group was (141.0± 20.0 mg/dL) and (95.3 ± 15.1 mg/dl ) among control (P.value was (0.001 )considered significant different ,the mean of serum HDL-C in combined oral contraceptive group was (43.3± 10.4mg/dL) and (56.5 ± 8.5mg/dl ) among control group(P.value was (0.004 )considered significant different and the mean of serum LDL-C in combined oral contraceptive group was (87.6±20.9 mg/dL) and (66.5±6.2mg/dl ) among control group(P.value was (0.001 )considered significant different .Most of percentage presented that age group 20- 30 years among case population and control as , Majority of them used contraceptive during 3 years, Majority of them had used Familia contraceptive then few used Marvelon. Conclusion: The study result concluded that women had received oral contraceptive had higher level of total plasma cholesterol, triglyceride, LDL-C while low level of HDL-C and insignificantly correlation between plasma total cholesterol and (age, body mass index, and duration of combined oral contraceptive use).