Determination of Complete Blood Count among Chronic Liver Disease in Ibn Sina Hospital-Sudan

Abstract

Liver is vital organs in the human body, it’s responsible of producing a number of hormones and enzymes besides storing several vitamins and when it gets sick this may affect the blood cells indicators. This is a case control study conducted in Ibn Sina Hospital in Khartoum State, Al Sahafa District in the period from October 2019 to February 2020. It aimed to find out the effect of chronic liver disease on the complete blood count. The study included 100 individuals, 50 individuals were infected with chronic liver disease and the other 50 individuals were seemingly healthy as a control group, patients’ data were taken through an organized questionnaire, blood samples were collected in EDTA container, complete blood count was measured via Sysmex XP300 device, data and results were analyzed using SPSS version 16.0 The study showed that there was a statistical reduction in the average count of red blood cells (RBC), the average concentration of HGB, the average volume of packed RBC’s (HCT) and the mean corpuscular volume (MCV) as well as the P value = (0.00) respectively. Likewise, the study figured out that there was a reduction in the average count of platelets (PLT) and the mean packed platelets’ volume (PCT) as well as the P value = (0.00) for both tests, conversely, the study found out that there was a statistical increase in the mean corpuscular hemoglobin concentration (MCHC) and the p value = (0.04), whereas no statistical difference was found in the mean corpuscular hemoglobin (MCH) where the P value = (0.44) and the mean platelets volume (MPV) where the P value = (0.33) as well as the average of white blood cells (WBC) where the P value = (0.66) This study concluded that chronic liver disease has an effect on red blood cells, hemoglobin, hematocrit, platelet count, plateletcrit, MCV and MCHC, and no difference on WBC, MCH, and MPV.