Diagnostic Significance of CK20 and CD15 Expression in Gallbladder Tumors

Abstract

This is descriptive retrospective study conducted at International Medical Center in Jeddah, Saudi Arabia. From September 2019 to January 2020. The study aimed to detect CK20& CD15 expression in Gallbladder tumors, using immunohistochemistry staining technique. Samples were collected from51 patients previously diagnosed as bladder tumors, 16 (31.3%) were benign and 35 were malignant (68.7%). their age ranges from 25 to 97 years with mean age of 60 years. (26) of them were females with percentage (51%) and 25 patients were males with a percentage (49%). The benign tumors samples 16 with percentage (31.3%) show negative result with CK20 & CD15. CK20 was positive in 31 (60.8%) samples and negative in 20 (39.2%) samples. Positive results in 13 samples of Adenocarcinoma with percentage (37.1%) and 18 in Transitional Cell Carcinoma with percentage (51.4%).CK20 was negative in 4 samples with percentage (11.5%). There is a significant correlation of CK20 & malignant gallbladder tumors (P-value=0.000) CD15 was positive in 9 samples with percentage (17.6%) and negative in 42 samples with percentage (82.4%), all the positive CD15 results were in Transitional Cell carcinoma. There is a significance correlation between CD15 expression and malignant tumors of gallbladder (P-value= 0.000).