Assessment of Plasma levels of Zinc and Copper among Sudanese with Chronic Renal Failure on Hemodialysis

Abstract

This is a cross- sectional, hospital - based study was carried out to measure the levels of plasma Zinc and Copper in Sudanese chronic renal failure patients treated with chronic hemodialysis attending Selma Renal Dialysis Centre, Khartoum state, during the period from March to July 2011. Sixty five Sudanese chronic renal failure patients treated with maintenance hemodialysis; including 40 males (aged 19-76years), and 25 females (aged 16- 70years), were enrolled in this study, also thirty apparently healthy individuals to serve as control group (aged 20-60 years); including 15 males, and 15 females. Five ml of venous blood were collected from each participant, the plasma obtained; Zinc and Copper levels were measured by Atomic Absorption Spectrophotometer (AAS). Statistical analysis of the obtained results revealed that; means of plasma levels of Zinc & Copper was significantly lower among chronic hemodialysed patients compared to control group (p value for Zinc = 0.000 ,Copper = 0.000) . In chronic renal failure patients Plasma levels of Zinc & Copper not influenced by age, sex, or the coexisting diseases. Plasma levels of Zinc were affected by hemodialysis duration (p value 0.004), but with a weak negative correlation, where as the plasma levels of Copper not influenced by hemodialysis duration. In conclusion depletion of plasma Zinc and Copper may contribute to the disturbed trace elements concentration in hemodialysed patients, and will be consider in the ‫‪treatment & follow up of chronic hemodialysed patients to well fitness &better‬‬ Life.