Assessment of Plasma Total Cholesterol, Low Density Lipoprotein Cholesterol and Uric Acid among Sudanese patients with Type 2 Diabetes Mellitus in Khartoum state

Abstract

Background and aim of study: Lipid abnormalities in patients with type 2 diabetes are a major problem and associated with the increased risk of cardiovascular disease (CVD). The study aims to estimate total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), uric acid (UA) and HbA1c among type 2 DM. Materials and Methods: This was cross sectional hospital-based study conducted from March to July 2022, at different diabetic centers(Sad Roshwan and Gabber Abo aleis )in Khartoum state among 300 Sudanese patients with type 2 Diabetes mellitus. 5 ml of blood samples were collected from type 2 Diabetes mellitus patients, 2ml put in EDTA container to estimate HbA1c level, and 3ml in heparin in order to estimate TC, LDL-C, UA level which measured by using enzymatic method and spectrophotometer device, and commercial reagent kits from Bio system company. The data obtained were analyzed by using SPSS version 26 computer program. Results: study showed 73% (n=219/300) of study group were poor glycaemic patients (HbA1c >7%). TC and LDL-C were significantly increased in poor glycemic type 2 DM, TC (245.1 ± 48.7 mg/dl vs 189.1± 23.9 mg/dl); LDL-C (158.4± 38mg/dl vs (110.5±21.5 mg/dl) when compared with good glycaemic. Moreover; HbA1c was significantly positive associated with TC (r=0.576; P=, 0.000). and LDL-C (r =0.552, P=0.000). Study revealed that there was insignificant difference in mean of UA in good glycemic control when compared with poor glycemic control. Conclusion: Sudanese with type 2 diabetic patients poor glycaemic control have increased plasma TC and LDL-C, HbA1c was significantly positive associated with TC and LDL-C. Study revealed that there was insignificant difference in mean of UA in good glycemic control when compared with poor glycemic control.