Assessment of Hemoglobin A1c, Triglyceride and Uric Acid in Plasma in Sudanese patient with Type 2 Diabetes Mellitus in Omdurman city

Abstract

Increased lipids level lead to several disease such as cardiovascular disease (CVD), and other heart diseases . To assess HbA1c, plasma Triglyceride and Uric acid among type2 diabetic patients Materials and methods: This was a cross sectional hospital based study, conducted in Omdurman city, the period from March to August 2022. The study included 300 Sudanese diabetic patients with type 2 from both sex. Five ml of blood sample was collected, 2 ml in EDTA container for HbA1c estimation and other 3 ml in Heparin container for Triglyceride and uric acid estimations. The HbA1c was measured by using fine care instrument, plasma triglyceride and plasma uric acid were measured by enzymatic methods using spectrophotometer DIRUI DR-7000D ; The data obtained was analyzed by used SPSS version 26 program. Results: The study showed 60% (n =181) was female and 40% (n =119) was male. The study showed 27% (n=81) of patients were good glycemic control and 73% (n=219) were poor glycemic control based on HbA1c values. Plasma triglycerides was significantly increased in Poor glycemic when compared with good glycemic patients with P-value (0.000). More over; 86.8% (190/300) of poor glycemia type 2 DM had hypertriglyceridaemia. However; plasma uric acid was insignificant increased in poor glycemic when compared with good glycemic control P- value >0.05.in addition 30.6% (67/300) of poor glycemic type 2DM had hyperuricemia. HbA1c had positive correlation with plasma triglycerides (r=0.517, p value=0.000); and insignificant correlation with plasma uric acid (r =0.069, P- value= 0.729). Conclusion: The Sudanese patients with poor glycemic control type 2 DM had increased in plasma triglyceride and normal plasma uric acid.