Clinical Significance of CBC Parameters and Peripheral Blood Morphology in the Diagnosis of Covid19 in Khartoum State 2022

Abstract

Hematological parameters can be affected by many diseases. Corona virus is one of recent pandemic that affect many hematological parameters. Wuhan city reported a cluster of cases of atypical pneumonia with unknown etiology in December 2019.Subsequent contrast led to identification of a “novel” coronavirus that had caused the disease. Measurement of complete blood count parameters and peripheral blood morphology is necessary for the diagnosis and medical care of covid19. This is a case control study conducted through the period from February 2022 to April 2022 in Gebra quarantine in Khartoum state. The study population comprise two groups of adults in different ages for both sex (male 59% and female 61%) in age range from (18 to 85 years old). Two hundred subjects were recruited for this study, hundred patients with COVID-19 infection and hundred healthy volunteers as control group. The data was collected using laboratory investigation to obtain complete blood count parameters and peripheral blood morphology results. Data collected using structured questionnaire which include general information and anverbal consent wasobtained. Three ml venous blood were collected from all participants and placed in EDTA anticoagulant containers. The data analyzed by SPSS version. The study revealed that Neutrophil, MPV, PDW, PLCR,NLR, WBCs and MCHC values of case group were significantly higher values (P.V 0.000),(P.V 0.000),(P.V 0.000),(P.V 0.000),(P.V 0.000),(P.V 0.000),(P.V 0.000) respectively compared to control group. Hemoglobin, Lymphocyte, Platelet, MCV, MCH and RBCs parameters of case group were significantly lower values (P.V 0.000),(P.V 0.000),(P.V 0.000),(P.V 0.000),(P.V 0.000),(P.V 0.000) in patients with COVID-19 compared to control group. The study concluded that COVID-19 patients share a common pattern of complete changes in morphology and blood count parameters. In this study it is observed that there is no significant relationship between patient’s gender and COVID-19. Where there is a significant relationship between patient’s age and COVID-19.