In- vitro – Anticoagulant Effect of zingiber officinale (ginger) aqueous extract on normal human plasma in Khartoum sudan

Abstract

Background: Haemostasis is the process of forming clots in the walls of damaged blood vessels to prevent abnormal bleeding and to maintain intravascular blood in a fluid state. Ginger is largely universal staple herb, popular throughout history and it has been consumed for treatment of different disorders. Objective: This study aimed to examine the effect of ginger aqueous extract on Prothrombin Time among Adult Healthy Volunteers. Method: Total Fifty (50) healthy adult volunteers in this study; 25 of them were females and 25 were males; age ranged between 15 t0 30 years. In vitro anticoagulant effects of ginger aqueous extract (5%) in different volumes (25, 50 and 75 μL) were examined in the blood samples of normal individuals by measuring prothrombin time (PT). Results: The result show that mean of Prothrombin time level was found significantly higher in the samples collected after addition of ginger aqueous extract (25,50 and 75%) than that of samples collected before addition of extract (Mean±SD: (13±1), (15±2), (17±2) and (20±3) respectively, P.value 0.000). No statistically significant difference was found in the mean of Prothrombin level between different sex and in different age in both pre- and post-ginger aqueous extract (25, 50 and 75%) samples with p.value more than 0.05. Conclusion: ginger aqueous extract in different concentration inhibited clot formation and increased prothrombin time. ginger can b used as a supplementary anticoagulant agent to improve and/or prevent cardiovascular disorder