Assessment Plasma Levels of Alkaline phosphatase ,Total Bilirubin and Direct Bilirubin among Sudanese Patients with COVID 19 at Khartoum State

Abstract

Background: Corona virus disease is challenging in everyday lives because it has devastating effects on human health and well-being and negative impact on economy. Aim: this study was amid to assess of plasma levels of alkaline phosphatase, total bilirubin and direct bilirubin among Sudanese patients with COVID 19 at Khartoum State. Material and methods: this was case control study conducted during the period from February to June 2022. fifty patients with covid 19 collected as case group compared with fifty healthy individuals as control group. patients and control were from Jabra isolation center and Advance Diagnostic Laboratory respectively. Blood samples were collected from both groups and serum levels of (ALP, total bilirubin and direct bilirubin) were estimated using full automated instrument spin react 200. the procedure of biochemical test was performed according to manufactured instruction. statistical test was done using SPSS version 25. Results: this study was showing no significant deference in mean ± SD of serum ALP in covid patient (98.6 ± 16.3) U\L versus control (83.7±14.4) U\L with p value (0.11). but mean ± SD of serum total and direct bilirubin were significant higher in covid patient (2.3±0.35, 0.79±0.73) U\L compared with control (0.79±0.23, 0.37±0.19) U\L with p value (0.00, 0.00) respectively. There were no significant difference of serum total and direct bilirubin cross gender in case group with p value (0.69, 0.25) respectively. in other hand serum ALP show significant higher in male compared with female in covid patient with p value (0.04). There was no association between biochemical parameter (ALP, total bilirubin and direct bilirubin) and study variable (age and duration of disease) in study group with p value (0.078, 0.56, 0.23), (0.80, 0.82, 0.92) respectively. Conclusion: This study concluded that there was increased in the level of total and direct bilirubin in case compared with control group. an ALP levels was also increased in male compared with female in Sudanese patient with covid-19.