Evaluation of Platelets Indices in Malaria Patients in Khartoum State

Abstract

Malaria is a life threatening disease caused by parasites that are transmitted to people through the bites of infected female anopheles mosquitoes . In Sudan there is a high prevalence of malaria. A number of studies have been conducted to determine the magnitude of the effect of malaria and the mortality rate among members of the community and these one of them , these study to determined the effect of malaria in Khartoum patient . This is a case control study conducted at Saad Rashwan hospital in Khartoum state at the period of February to April 2020. The study aimed to measure platelet count and indices in malaria patient . Two hundred blood sample were collected in ethylene deaminatetraacitic acied (EDTA) containers , 100 samples from malaria patient and 100 sampls from apparently healthy volunteers as control. Platelet count and platelet indices were measured using automated hematological analyzer (Sysmex BC-3000 PLUS).The study showed a thrombocytopenia among malaria patients when compared to the control. Mean of cases 233X109/L, while the mean in control group is 290X109 (P.value= 0.00). MPV was increased in patients when compared to control group (Mean of patient is 9.3, Mean of control is 8.4, P. value= 0.00). PCT showed no significant difference when compared to control group mean in patients 0.2197 , Mean in Control group is 0.2427, P. value=0.150). PDW was decreased in patients comparing to control group (Mean of patients is 11.372, means of control group is 14.031 P. value = 00.0). In this study the age and gender had no effect on platelet count ,MPV,PDW and PCT. The study concluded that malaria altered the blood count causing thrombocytopenia and increased MPW and decreased in PDW but no significance difference in PCT.