Immunohistochemical Detection of Ki67 Expression in Endometrial Cancer among Sudanese women

Abstract

Endometrial carcinoma is one of the commonest gynecological malignancies.Ki67is a typical immunohistochemical marker for cell proliferation. Ki67monoclonal antibody is a promising tool for determining cell proliferation on routine histologic materialit is increasingly popular due to its minimal tissue requirements and suitability to routinely fixed tissues. Thisdescriptive, retrospective hospital based study aimed to detect the expression of Ki67 in endometrial cancer,it is was conducted in Omdurman Maternity Hospital during the period from January 2021 to May 2021 Fiftyformalin fixed paraffin embedded tissue blocks were selected, then applied to immunohistochemistry technique The Fifty women age ranged between 21 years to 76years, the mean age was 48.5 years old, result of immunohistochemistry showed that;Ki67 expression as follow 29 (58%) female were less than 38% considered as negative result and 21 (42%) were more than 38% considered as positive result,expression of more than 38% were distributed not detected in grade I, 3(6%)cases seen in grade II and 18(36%) cases seen in grade III, with significant relation between the expression of ki67 and cancer grade ( p.value :0.000) The study concludethat there is a significant correlation between Ki67 expression and cancergrade.