Study of Some Hematological and Biochemical Parameters ofBabesiosis in sheep In Shikan Locality – North Kordufan State – Sudan

Abstract

The aim of this study was to evaluate some hematological and biochemical parameters of ovine babesiosis in Shikan Locality North Kordufan State. A total of 150 samples of whole blood and blood for serum were taken from the jugular vein of suspected sheep which clinically examined for heart rate, respiratory rate, and body temperature. For identification of the protozoan , GIEMSA- stained blood smear method was used .Also homological (hemoglobinconcentration, red blood cells, hematocrit red cell distribution width, platelet distribution width, mean platelet volume and platecrit) and biochemical (Total protein, albumin,globulin, urea, creatinine, cholesterol, and triglyceride) Parameters were measured . The results reveled that all health parameters were elevated in infected animals (20 animals) compared with negative infected animals (76) and control animals (54) to ovine babesiosis. There was decrease of hemoglobin concentration (4.83±087), hematocrit (13.2± 5.77) and red blood cell counts (3.42±1.10) compared with control animals (9.11 ±1.24) (21.06±6.55) (6.24±2.54 respectively). But there was slight increase of red cell distribution width (19.1±6.37) and mean platelet volume (7.23±1.94) Compared with control animals (18.3± 4.05) (6.85±1.38) respectively). Infected animals with parasiteinvestigated for biochemical alterations revealed that an elevationin total protein (8.97±0.80), globulin (5.40±1.0), urea (34.5 ± 9.26) creatinine (1.14±0.41), Cholesterol (55.0±16.26) and triglyceride (59.9±18.99). The albumin (3.19 ±0.300) was lowered.Diminazene acetureate was given at dose rate 2mg/kg b.wt.., I/M single dose followed by supportive therapy given based on requirement of the individual case and no death recorded. In conclusion sheep with babesiosis showed variable depletion in level of hemoglobin, red blood cells, hematocrit, platelets, plateletcrit and mean cell volume, in infected sheep babesiosis serologically total protein, urea, creatinine, globulin, cholesterol and triglyceride revealed variable increase compared to healthy sheep in all parameters evaluation of the results leads to the suggestion that severe anemia resulted from Babesiaovis infection may cause kidney and liver damage in sheep with babesiosis. Consequently, the investigation of kidney and liver elements would be a useful way to follow the prognosis of the disease, as well as to provide supportive therapy to reduce potentialkidney and liver effects.