Frequency of Hepatitis ( B) Virus among Hepatocellular Carcinoma Patients in Khartoum State

Abstract

Hepatitis B is infectious disease caused by hepatitis B virus ( HBV ) which affects the liver and may cause hepatocellular carcinoma.It is the most common type of primary liver cancer in adults, and the most common cause of death in people with liver cirrhosis It occurs in the setting of chronic liver inflammation, and is most closely linked to chronic viral hepatitis infection (hepatitis B or hepatitis C).The aim of this study was to determine the frequency of HBV among hepatocellular carcinoma patients. This Study was conducted during the period between February and May 2019. Atotal of one hundred patients with hepatocellular carcinoma were enrolled in this study. The patients were hospitalized in Khartoum Radio Isotop Therapy Hospital. Blood sample was collected from each patient. Serum was obtained then examined for the presence of HBsAg using Enzyme Linked Immune Sorbent Assay ( ELISA ). This study included patients age which is ranged from I up to 80 years. The results showed that out of 100 hepatocellular carcinoma patients (HCC) investigated71(71%) were positive for HBsAg, while 29 (29%) were negative .Regarding gender 55(55%) of studied patients were males while 45(45%) were females. high of positivity result observed among males 40 (56.3%). Regarding age patient were grouped in to four group, most of patients under study belonged to 41-60 age group, the high positivity result was observed among age group 21to 40 years 29(40.8%), while high negativity result observed among age group 41to 60 years 14 (48.3%). In this study there was an association between age and HBV among HCC ( p. value =0.001) The study concluded that the HBV infection in hepatocellular carcinoma patients is so high and the level of infection is higher in males than females. Further studies with large number of samples and controls group and more advanced technique are required to validate these results.