Assessment of Triglycerides to High Density Lipoprotein Cholesterol Ratio and C-reactive Protein among Type 2 Diabetic Patients in Khartoum State

Abstract

Background: cardiovascular diseases is the most important cause of morbidity and mortality among patients with type2 diabetes mellitus and the TG:HDLc ratio recently used as predict subject at increased risk of developing metabolic and cardiovascular complications and HDLc level are inversely related to plasma TGs level and there is a dynamic interaction between high density lipoprotein and triglycerides rich lipoprotein in vivo. Method: The study includes 52 diagnosed diabetic patients (14 male and 38 female) and 52 apparently healthy individuals (control) (14 male and 38 female) and Age was matched (32_70) years all samples were collected from Ombada Hospital and El-emtiaz medical center, from 12 November to 1 September. Statistical procedure was followed using statistic package for social science (SPSS) version 16 on programmed computer. Result: The result showed a significant increase in TG: HDLc ratio among type2 diabetic patients in comparison with control group (9.2±6.9, 1.69±0.47mg/dl), for mean and standard deviation for case and control respectively with P-value 0.016, significant increase in TGs between type2 diabetic patients in comparison with non-diabetic group(169±116, 88±17.5mg/dl), for mean and standard deviation for case and control reactively with P-value 0.056, significant decrease in HDLc among type2 diabetic patients in comparison with control group(34±14, 50±9.5 mg/dl), for mean and standard deviation for case and control respectively with P-value 0.000, significant increase in percentage of CRP among type2 diabetic patients in comparison with control group (33%, 0.0%), with P-value 0.02 for case and control respectively and insignificant difference in BMI between type2 diabetic patients and control group (22±4.8, 21±3.8kg/cm2) for case and control respectively with P-value0.677. Also no correlation between ratio and age, BMI, duration, among type2 diabetic patients with P-value) p =0.325), (p =0.800), (p =0.130) respectively, No correlation between HbA1C and Age, BMI, duration, among type2 diabetic patients with P-value (p= .977), (p= .208), (p = 0.604) respectively. Also no correlation between CRP and age, BMI, duration, with P-value (p = 0.613), (p =0.306),( p =0.588) respectively, no correlation between HDLc and Age, BMI, Duration with P-value(p =0.607), ( p =0.825), ( p =0.230) respectively, and no correlation between TG and Age, BMI, Duration with r and P-value (p =0.244), (p =0.561), (p =0.215) respectively in conclusion type2diabetes mellitus had increase HbA1c, TGs, CRP, TG:HDLc ratio and deteriorated HDLc compare with non-diabetic group. Conclusion: In conclusion type 2 diabetic patients had increased triglycerides and triglyceride / high density lipoprotein cholesterol ratio, decreased high density lipoprotein cholesterol and more positively CRP results compared with control group and no difference observed in BMI among type2 diabetic patients compared with control group .No correlation between TG, HDLc, TG: HDLc, HbA1c and CRP with age, BMI, Duration among type 2 diabetic patients.