Association of Antithrombin III Level , Platelate Count and Platelates Indices among Sudanese Hypertensive Pregnant Women in Khartoum state

Abstract

This was analytical case controle study conducted in Khartoum state during the period of January to Octoper 2019 aimed to detect Antithrombin III level deficiency and determine Platelet count and platelet indices in hypertention pregnant women . A total of 80 subject enrolled in this study , 40 of them worked as cases (pregnant women with hypertention) and the other 60 worked as controls (Normal pregnant women), Control pregnant women were matched to cases in age group . Venous blood samples (2.5 ml) were collected from the participants in EDTA anticoagulant blood container and 2.7ml of venous blood in Tir Sodium Citrate container blood (TSC). All samples were tested using automated hematology analyzer (sysmex XP-300) for measurement of PLTs count and PLTs indices and Accent 200 Antithrombin III kit for estimation of antithrombin level . Data were analyzed by statistical package for social science ( SPSS ) computer program version 20 ,this study pregnant women aged from 18 to 42 . In conclusion : This study concluded that the mean and standard deviation of Antithrombin III level of induced hypertention pregnant women 0.22±0.03 mg / dl , While , mean ± SD of ATIII level of normal pregnant women 0.32±0.06 mg / dl . A high significant decrease of AT III level in pregnant women induced hypertention in compare with AT III level in normal pregnant women (P. value = 0.00). Mean ± SD of PLT Count of induced hypertention pregnant women 188±41.9 (109L) , While , mean ± SD of PLT Count of normal pregnant women 233±39.1 (109L), A high significant decrease of PLT Count of induced hypertention pregnant women in compare with PLT Count of normal pregnant women (P. value = 0.00). Mean ± SD of MPV of induced hypertention pregnant women 11.37±1.53 (fl) , While , mean ± SD of MPV of normal pregnant women 10.45±1.58 (fl). Asignificant increased of MPV of induced hypertention pregnant women in compare with MPV of normal pregnant women (P. value = 0.01). Mean ± SD of PDW of induced hypertention pregnant women 16.25±1.86 (fl) , While , mean ± SD of PDW of normal pregnant women 15.29±2.04 (fl) ), there is a significant increased of PDW of induced hypertention pregnant women in compare with PDW Count of normal pregnant women (P. value = 0.030). Mean ± SD of PCT of induced hypertention pregnant women 0.21±0.05 (%), While , mean ± SD of PCT of normal pregnant women 0.24±0.06 , there is a significant decrease of PCT of induced hypertention pregnant women in compare with PCT of normal pregnant women (P. value = 0.015). There was no correlation between AT III level , PLT Count , MPV , PDW and PCT with age and contraceptive. There was moderate positive correlation between AT III and PLT count , a week negative correlation between AT III and MPV , week negative correlation between AT III and PDW ,a week positive correlation Between AT III and PCT. deficiency patients were detected by specific Antibody an Immunological complex protocol. Full absent of Antithrombin111 deficiency not dedected . Have been detected neither Antithrombin111 level nor Antithrombin111 activity.