Determination of The Effects of Elapsed time Chemotherapy Treatment on Radio Nuclide Bone Scan Image Quality for patient on ca-breast

Abstract

The bone scan is the accepted initial imaging modality for skeletal metastases. Some patients use chemotherapy in the initial stages before and after surgery for breast cancer patients according to the international protocol; this study aimed to evaluate the time elapsed between the bone scan and chemotherapy dose It is a prospective study designed and conducted in the Nuclear Medicine Department, National Cancer Institute- Wad Madani, which included 50 female breast cancer All patients were diagnosed with breast cancer according to the histopathology report and were received chemotherapy treatment patients with mean age 48.22 years, and their mean weight 74.7 kg, mean dose 25.4 mci ⁹⁹ᵐTc-MDP, were investigated via bone scan with MEDISO gamma camera The duration of the study was from March 2019 to July 2019 .The results of this study showed that the direct linear relationship between the acquired counts and the elapse time after chemotherapy , the coefficient of this relationship indicates that the count will be increased by 26 kilo counts per day . their is a direct positive relationship between the patient weight (kg) and the administered dose (mci) ,when the weight of the patient increase must be increasing the doses. So the longest the interval time between last chemotherapy and bone scan the more image will be high optimal, where it was preferred to be more than three weeks.