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Correlation between patient’s risk factors and H. pylori infection and Seroprevalence of anti- Helicobacter pylori IgG and IgA among out patients in Khartoum State, Sudan with different diagnostic tests

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dc.contributor.author H. S, Orsud
dc.contributor.author AE. O., Mergani
dc.contributor.author S. M., Elsanousi
dc.contributor.author G. E, Mohammed
dc.date.accessioned 2020-10-15T10:23:32Z
dc.date.available 2020-10-15T10:23:32Z
dc.date.issued 2020-06-01
dc.identifier.citation H. S, Orsud. Correlation between patient’s risk factors and H. pylori infection and Seroprevalence of anti- Helicobacter pylori IgG and IgA among out patients in Khartoum State, Sudan with different diagnostic tests/ Orsud H. S., Mergani AE. O., Elsanousi S. M.1 and Mohammed G. E.- vol 21 , no 1 article en_US
dc.identifier.issn 1858-6716
dc.identifier.uri http://repository.sustech.edu/handle/123456789/25191
dc.description.abstract This study was conducted to detect seroprevalence of anti- Helicobacter pylori IgG and IgA antibodies by different serological techniques and to evaluate the diagnostic efficiency and reliability of these techniques including Immunochromatography test ICT for rapid H. pylori IgG antibodies detection, enzyme linked immunosorbant assay (ELISA) test for H. pylori IgA antibodies detection and ELISA for determination of Anti-Helicobacter pylori IgG titer. Two hundred and thirty five patients were subjected to blood sampling and data collection in a questionnaire form, consequently the statistical correlation was tested between H. pylori infection and patient’s risk factors (Age, Gender, Smoking history, Body mass index, Hypertension, Diabetes mellitus, symptoms and H. pylori infection history). The IgG antibody titer mean was 95.21 RU/ml and the maximum was 299.20 RU/ml while every sample above 22 RU/ml was considered positive according to manufacturer, the positive samples for IgG were quite high (88.2%) while for IgA the positives were 30% and the positive cases by ICT were 71.9%. In Sudan and similar developing countries ICT is considered as the most commonly used test for diagnosis of Helicobacter pylori infection, this study showed that ICT accuracy was 74.6%, Sensitivity was 75.6% and the Specificity of this test was 88.2%. Hence it is highly recommended that this test should be replaced by other more trusted (invasive or non-invasive) laboratory diagnostic procedure. While the ICT method is not very reliable. en_US
dc.description.sponsorship Sudan university of science and technology en_US
dc.language.iso en en_US
dc.publisher sudan university of science and technology en_US
dc.subject ELISA en_US
dc.subject ICT en_US
dc.subject Helicobacter pylori en_US
dc.title Correlation between patient’s risk factors and H. pylori infection and Seroprevalence of anti- Helicobacter pylori IgG and IgA among out patients in Khartoum State, Sudan with different diagnostic tests en_US
dc.type Article en_US


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