Immunohistochemical Detection of CD10 among Sudanese Patients with Renal Tumors

Abstract

This is retrospective case control study conducted in Omdurman teaching hospital during the period from January 2017 to Augustus 2017. The study aimed to detect the expression of CD10 in renal tumors using immunohistochemistry. Atotal of 30 fixed paraffin blocks previously diagnosed as renal tumors, 10 (33.3%) samples were benign tumor and 20(66.7%) samples were malignant tumor were selected for this study. One section of 3 microns was cut from each block and stained by immunohistochemistry (avidin Biotin technique) for CD10 detection. The data obtained were analyzed using SPSS computer program version 15. The patients ages ranged between 11-87 years with mean age of 49 years, most of them 23(76.7%) were above 50 years and the remaining 7(23.3%) were under 50 years. Regarding gender patient revealed that 19(63.3%) patients were males and 11(36.7%) patients were females. CD10 was positive in 20(66.7%) samples divided as follow; 15(50%) malignant and 5(16.7%) benign, while 10(33.3%) samples were negative 5(16.7)malignant (16.7)benign, with insignificant correlation between CD10 expression and renal tumors p-value (0.183). The study concluded that there is no relation between CD10 expression and histological dignosis of renal tumors.