Toxicity of Furdan (Carbofuran) in Nubian Goats

Abstract

Oral toxicity of Furdan (Carbofuran) were examined in fiftteen healthy Nubian goat kids 5-6 months old and weighing 10-12 kg.They were divided randomly into 5 groups each of 3. Furdan was dosed at the rate of 10, 5, 2.5 and 1.25 mg/kg body weight/day to groups 1, 2,3 and 4 respectively. Group 5 was control. The most observable clinical signs were excessive salivation, lacrimation, mydriasis, dyspnoea, abduction of forelimbs, convulsive seizures, tremors, paresis of the hindlimbs, imbalance, recumbency and death. Postmortem lesions were varying degrees of haemorrhages and congestion in the brain, heart, lungs, liver, kidneys and small intestines. Histopathological findings were satolytosis in cerebral tissue, pulmonary emphysema and edema, centrilobular hepatocytic degeneration, cortical renal tubular epithelial cells degeneration and glomerular shrinkage and gastrointestinal erosions. The values of Hb, RBC count; MCH and MCHC were decreased while the value of MCV was increased significantly. No significant changes were observed for the values of PCVandWBC and in serum concentrations of Na, K, Mg, Ca, P, Cu, Fe, total proteins, albumin, globulinsl, total bilirubin and urea and for serum activities of ALT and ALP. Significant increases in serum AST activity and decreases in serum concentrations of glucose and iron