In vitro Adulticidal Efficacy of Albendazole, Capparis decidua stems and Moringa oleifera leaves against Fasciola gigantic

Abstract

The in vitro adulticidal effect of aqueous and methanolic extracts of Capparis decidua stems, Moringa oleifera leaves and albendazole was investigated against Fasciola gigantica worms. Three different concentrations of the plant extracts 1200, 600, 300 ?g/ml and 1%, 0.5%, 0.25% of albendazole were used. Albendazole drug exhibited highest mortality (P < 0.05) after 11 hours. C. decidua stems methanolic extract showed significant (P < 0.05) toxic effect on F. gigantica adult worms after 13 h at 1200 ?g/ml compared with the low concentration of albendazole (0.25%). Moreover, methanolic extract of M.oleifera leaves did not show any significant (P > 0.05) fasciolicide activity against adult worms at the concentrations used in this study compared with albendazole and the negative control. These results demonstrate that C. decidua stems may have anthelmintic activity especially at higher doses.