Serum Level of FSH and LH among Females with Sickle Cell Anemia in Khartoum State

Abstract

Sickle-cell disease (SCD), also known as sickle-cell anemia (SCA), is a group of genetically passed down blood disorders. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This is a case control study conducted during the period from February to December2016, to determine the level of Gonadotropins (follicle stimulating hormone and Luteinizing hormone) among Sudanese female with sickle cell patients, the level of gonadotropin was estimated by using ELISA. Eighty subjects were included in this study (50 patients {40 sickler, 10traits} and 30healthy) Statistical analysis was done by using SPSS. And the result showed that follicle stimulating hormone level was significantly higher in sickler group when compared to non sickler group (5.82±4.26 Vs 3.80±2.09 .pvalue = 0.00). And luteinizing hormone did not show significant different in sickler group when compared to non sicklergroup (4.61±3.23 Vs4.52±3.43 p.value = 0.947). .The study also revealed that a significant positive correlation between follicle stimulating hormone and age.(r= 0.316,p value= 0.04) and also a significant positive correlation between luteinizing hormone and age.(r =0.405, p.value = 0.009) A significant negative correlation between follicle stimulating hormone and duration of treatment by Hydroxyurea (r =-0.447,p.value =0.045). And also show a significant negative correlation between luteinizing hormone and duration oftreatment by Hydroxyurea. (r =-0.538,p.value =0.039) In conclusion the serum level of follicle stimulating hormone is increase in patients with sickle cell disease, and luteinizing hormone is not affected Also there were relationship between the level of follicle stimulating hormone, luteinizing hormone and duration of treatment, eventually there was association of increasing in age and duration of sickle cell disease in patients with sickle cell disease in the increase level of follicle stimulating hormone, luteinizing hormone