Measurement of some coagulation profile (PT, APTT, INR and platelets count among pregnant women in Khartoum State

Abstract

This is an analytical and prospective study was carried out in Khartoum state, in the period from October 2014 to December 2014 in order to study hemostatic changes (PT, APTT, INR, PLT count) that occur during pregnancy. Blood samples were collected from 100 women with normal pregnancy attending to al-exer specialized medical center in Khartoum state, and compared with 50 normal non-pregnant women. Samples were collected in two containers (EDTA and trisodium citrate anticoagulants) and analyzed using sysmex device to obtain PLT count, and analyzed by Coagulometer to obtain (PT,INR, APTT and platelets ). Results analyzed statistically by SPSS program to compare parameters values in pregnant with non-pregnant women. Results show significant difference in mean and p.value of two groups, PLT count were significantly decreased in pregnant women in compare to non- pregnant, PT, APTT and INR also show lower value than in non- pregnant women. In conclusion there is in -significant difference in PLT count, PT, APTT and INR in pregnant women in different ages but that parameters may show difference results in each trimester of pregnancy where as In the first trimester PT and INR mean were decreased when compared to second and third trimester of pregnancy, APTT mean show small difference on three trimesters, in other hand plt count mean show minimal decrease in the first trimesters , moderate decrease in second trimester and in the third trimester plt markedly decrease