Association of Human Papilloma Virus with Non-melanoma Skin Cancer in Khartoum state

Abstract

This descriptive retrospective cross sectional study was carried out in Omdurman teaching hospital, during the period from March to October 2015, to detect the association between human papilloma virus infection and non-melanoma skin cancers. The study included 40 formalin fixed paraffin embedded blocks previously diagnosed as skin cancers , 20 samples were diagnosed as squamous cell carcinoma and 20 samples were basal cell carcinoma. From each block only one section with 3µm in diameter were cut, to detect HPV using immunohistochemical method by modified indirect method of Thermo manufacture. The patient data were collected from patient file`s. Data were analyzed usingSPSS computer program, frequencies, mean, chi square test were calculated. Among study group 26(65%) were males and 14(35%) were females, their age ranged between 20-90 year with mean age 63year. The immunohistochemical result of HPV among study group were positive in 14 (35%) cases,11 of them were SCC and the remaining were BCC while negative in 26 (65%) cases,17 of them were BCC the other 9 were SCC and with a significant association between HPV infection and type of skin cancer (P.value 0.008) . The result of sex in study group showed 12 were male and 8 were female in SCC, while 14 male and 6 female in BCC , with no relation between sex and type of skin cancer. The study revealed that the patient in age group >60 were 15 patient and remaining 5 were <60 in SCC, while in basal cell carcinoma 10 were <60 and other 10 were >60 years. The study concludes there is a significant association between HPV infection and type of skin cancers and no relation between age and sex with . type of skin cancer