Effect of Obesity on Some Coagulation Parameter in Obese Sudanese Subjects in Khartoum State

Abstract

This analytical case control study conducted in Khartoum State from March 2014 to May 2014 to measure the effect of obesity on some coagulation profile: Prothrombin Time (PT), Partial Thromboplastin Time (APTT) and International Normalised Ratio (INR). Basic information of participant which collect from questionnaire. Blood sample were collected from seventy obese subjects according to inclusion criteria and considered as case group and thirty samples were collected from not obese subjects and considered as control group. Twenty four of the cases were male, and the other Forty six were female. Thirty three of the cases aged less than thirty years and Thirty seven aged more than thirty year. Thirty three of the cases were obesity class I the body mass index was (30.00-34.99 kg/m2), Twenty nine of the cases were obesity classII the body mass index was (00.33-03.33 kg/m2) and eight of the cases were obesity classIII the body mass index was (≥ 40.00 kg/m2). Two milliliters of venous blood were collected from each subject by standard method. The PPP were tested for the PT, APTT and INR by using the coagulometer. The results revealed that there was significant decrease in PT level in case compared to control group (12.2±0.7sec Vs 13±0.8 sec) (P. value .000), INR result in case (0.97±0.06 Vs 1.03±0.07) compared to control group (P. value .000) and APTT level in case compared to control group (30.3±2.0sec Vs 32.6 ±2.1sec) (P. value .000). The age affect PT and INR results while APTT result not affect by age .There were no changes in PT, APTT and INR related to gender and obesity class. The study concluded that obesity have significant decreasing PT, APTT and INR.