Detection of anti Helicobacter pylori IgG antibodies in Typhoid Patients in Shendi Teaching Hospital

Abstract

The aim of study was to evaluate the prevalence of H.pylori among typhoid patients at Shendi teaching hospital. The study was conducted during the period from July 2014 to August 2014. Serum samples collected and preserved at -20oC. By using ELISA technique the seroprevalence of anti- Helicobacter pylori IgG was determined in sera of 72 case subjects out of them there were 64 (88.8%) positive. Twenty control subject were used, 10 (50%) of them were positive to presence of anti H. pylori IgG.The subjects were grouped according to age and gender. The study concluded that there was significant association between H.pylori and typhoid fever affected by age with no statistical difference in prevalence between smokers and non smoker also between coffee drinkers and non drinkers. The hypothesis for this association was that H.pylori may influence gastric acid secretion by urease enzyme and consequently increase susceptibility to Salmonella infection.