Abstract:
This study was conducted in medical core hospital, in Khartoum state
during period from April to August 2013.
Objectives: To evaluate Zinc level in pregnant women and its relation
with plasma triglyceride , total cholesterol ,HDL -cholesterol and LDL-
cholesterol among Sudanese pregnant women in Khartoum state.
Materials and methods: Blood sample were collected from 110
pregnant women (30 in first ,30 in second trimester and 50 in third
trimesters). In additional to 30 fertile non pregnant as control group,for
comparison of zinc and lipid profile .Plasma znic was estimated by
atomic absorption , and the lipid profile were estimated by colorimeter .
Indirect LDL-cholesterol were calculated via the Friedewald formula.
Result: The study showed significant decrease in zinc levels in the first
and second and third trimesters in the test group when compared with
reference group(0.44 ± 0.07 versus 0.68 ± 0.11 , 0.42 ± 0. 06 versus 0.68
± 0.11 and 0.40 + 0.8 versus 0.68 + 0.11 mg/dl respectively) , (p≤ 0.00).
Also the study illustrated significant decrease in first trimester and
increase in triglyceride in the second and third trimesters (94.8 ± 14.4
versus 105 ± 16.4 mg/dl, 108 ± 11.16 versus 105± 16.4 mg/dl, and 120 ±
17.6 versus 105± 16.4 mg/dl
respectively), (p ≤ .000). Significant
increase in total cholesterol was recorded in first and second and third
trimesters when compare with control group (189.4 ± 6.5 versus
160.0±16.6 mg/dl, 190.5 ± 14.3 versus 160.0 ± 16.6 mg/dl, and 191 ±
16.4 versus 160.0 ± 16.6 mg/dl respectively) ,(P ≤ 0.00 ).The study
showed significant increase LDL-cholesterol in the three trimester (148.8
± 7.9 versus 112.0 ± 17.0 mg/dl, 153.2 ± 15.0 versus 112.0 ± 17.0 mg/dl,
and 155.1 ± 185 versus 112.0 ± 17.0 mg/dl respectively),( p ≤ 0.00). In
contrast HDL-cholesterol is significantly decreased in the three trimester
(40.5±8.1 versus 48.0 ± 6.2 mg/dl, 37.4±6.8 versus 48.0 ± 6.2 mg/dl, and
35.8±8.0 versus 48.0 ± 6.2 mg/dl respectively), ( p≤ 0.00 ).The study
noticed
significant positive correlation between znic and HDL-
cholesterol in the three trimester of the test group (p≤ 0.05). Whereas znic
is significantly negatively correlated with LDL-cholesterol in the three
trimester of the test group (p≤ 0.05 ), and triglyceride and total
cholesterol recorded insignificant negative correlation with znic in the
three trimester of the test group (p≥ 0.05),
Conclusion: The study demonstrated decreased znic and HDL-
cholesterol level, and increased triglyceride, total cholesterol and LDL-
cholesterol in pregnant women. The decreases or increases is exacerbated
as gestational age increases.
