Abstract:
Sickle cell anemia is a common disease in Sudan. The patients
suffer from hemolytic anemia and other serious complications. The
underlying pathology of much of these complications is the occurrence of
vaso-occlusion due to micro thrombi formation resulting in organ
ischemia. Activation of coagulation system as increased Fibrinolysis has
been reported in SCA.
Sixty eight Sudanese patients of both sexes with ages ranging
between 6 months and 26 years were included in this study. 20 apparently
healthy controls were also studied to evaluate the activation of
coagulation system, and then the collected data were analyzed using
SPSS computerized programmed.
PT, APTT, and fibrinogen level were measured in all patients and
controls. The period of the study was from March to July 2009.
All controls have normal PT, APTT, and fibrinogen level. While
the mean of all patients have normal fibrinogen level with normal PT.
57% of patients had normal APTT, 31% had prolonged, and 12% had
shortened APTT.
The shortened APTT in some of the patients is an indication of a
hypercoagulable state while the prolonged APTT in others is suggestive
of a state of DIC.
