Abstract:
This was comparative, cross-sectional and analytical study has been carried out in
Algadarif state from May to August 2009. The study aimed to determine the level of D-
dimer inorder to detect the significance of activated fibrinolysis in sickler patients
randomly (steady state and non steady state). Sixty one blood samples were collected into
trisodium citrated containers (2.5 ml) from sickler patients in steady state or crises.
Fifteen control samples were collected from healthy people matched with age and sex of
patients.
All samples were investigated for PT, PTT, and INR was calculated using full automatic
coagulation analyzer CA-500, D-dimer was investigated using NycoCard D-dimer Single
Test.
Data were analyzed using program of Statistical Package for Social Sciences (SPSS).
The study revealed that the mean level of D-dimer was higher in all sickler patients
(whether in steady state or in non steady state), and the P value was (0.000) when
compared with control. But (P values > 0.005) in case of PT, PTT&INR and this means
the differences were not significant.
Also the study revealed that no significant difference between patients in steady state and
non steady state for the parameters of PTT and D-dimer (p 0.736 and 0.721
respectively) ,while significant difference was found in PT&INR(P 0.004 and .003
respectively).
The study concludes that the activation of fibrinolytic process does not associate with
patient clinical state, but associated with inheritance of Sickle Cell Disease .PT& INR
values can be effective in follow up of sickler patient’s thrombotic crises.
Very important recommendation that more studies on larger number of patients must be
done to detect the invivo cause of fibrinolysis activation, and to detect the diagnostic test
for crises.
