Abstract:
This is a prospective study was conducted during the period from
October 2004 to December 2005 at Khartoum Center For Dialysis and
Kidney Transplantation.
88 patients with end-stage renal disease ESRD under regular
haemodialysis (twice a week) were selected randomly with different ages
and sexes, to compare the plasma cholesterol and triglycerides pre and post
haemodialysis.
Plasma cholesterol and triglycerides were measured pre and post
haemodialysis in order to assess the effect of haemodialysis on cholesterol
and triglycerides concentration.
Preliminary investigations obtained from this study revealed that the
majority of patients with end-stage renal disease (ESRD) were presented
with other diseases namely hypertension 73.86 %, diabetes mellitus 11.36
%, renal stone 19.31 %, and also infestation of Hepatitis virus (HBV) were
found in a bout 10.22 % of patients with end-stage renal disease.
The findings of this study also showed that patients with end-stage
renal disease (ESRD) exhibited have increase plasma cholesterol pre
haemodialysis as a result of renal failure and there is a significant increase
in the mean of cholesterol post haemodialysis. (Being 148.73 and 169.14
mg/dl before and after haemodialysis respectively.
The results of this study showed that plasma triglycerides in patients
with end-stage renal disease maintained anon significant increase in the
mean of plasma triglycerides post haemodialysis, being 184.48 and 193.74
mg/dl before and after haemodialysis respectively.
No statistical difference in plasma cholesterol concentration were
found between males and females.
The age appeared to have no effect on the level of plasma cholesterol
and triglycerides concentration post haemodialysis.
The increase of plasma cholesterol and triglycerides among end-stage
renal disease under haemodialysis was reported to be due to heparin dose
given to the patients before haemodialysis to prevent clot formation in the
venous lines, which had aside effects include hyper lipidaemia,
thrombocytopenia and allergy (rare).
The results indicate that patients with end stage renal disease under
regular haemodialysis showed abnormalities of lipid metabolism, the
progressive elevation of plasma triglycerides could be relevant to the
development of cardiovascular disease in the patients and represent the main
causes of death.
A concluding from this study that patients under regular haemodialysis
had increased plasma cholesterol and may lead to hypercholesterolemia and
hence with increase risk of atherosclerosis and coronary heart disease and
lead to increase death rate among the patients with end-stage renal disease.
