Abstract:
This descriptive study was carried out in different pediatric hospitals in Khartoum
state during the period from November 2008 to February 2009. The study was
aimed to determine the ethnical and regional distribution of sickle cell anaemia
among patients referring to pediatric hospitals of Khartoum state. Complete blood
count, sickling test and haemoglobin electrophoresis were performed.
A total number of 100 samples were collected from patients referring to pediatrics
hospitals of Khartoum state, 81% of them with sickle cell disease and 19% with
sickle cell trait based on results of haemoglobin electrophoresis. Females represent
53 of the studied patients where as male 47.
The study also aimed to determine the anaemia parameters among patients with
sickle cell disease and trait and to make a comparison between sickling test and
haemoglobin electrophoresis.
The results were showed that sickle cell anaemia is predominant among tribes of
Western Sudan (88 % of cases) with highest frequency among Messeria tribe 31%
of cases followed by Rezigat 13% and Four 11% of cases, Dbania from eastern
Sudan 4% , Dinka from southern Sudan 2%.
This study showed that results of sickling test always agree with results of
haemoglobin electrophoresis.
The mean values of RBCs, Hb, PCV values are decreased in sickle cell disease, in
sickle cell trait mean values of Hb, PCV slightly decreased and mean RBCs are
normal, while red cell indices are normal in both sickle cell disease and trait.
