Abstract:
A prospective study conducted during April to August 2013 to compare serum
level of calcium, phosphorous, alkaline phosphatas activity of 50 apparently
health individual cigarette smokers and 50 apparently health individual
nonsmokers as control group from Khartoum state.
Blood specimens were collected from both groups and serum levels of
calcium, phosphorous and alkaline phosphatas were estimated used
Spectrophotometeric methods. Statistical package for social science
(SPSS version 11.5) computer software was used for data analysis.
Mean ± SD age (35.13 ± 15.46, 31.24 ± 10.20) for smokers and nonsmokers
respectively. Mean of smoked cigarette and duration of smoking (11.36 ± 8.4, 12
± 11.37) respectively. Comparison of estimated biochemical parameters in this
study showed at P≤ 0.005. There means no significant difference in calcium and
phosphate Levels between smokers and nonsmokers with p-value (0.44, 0.54)
and mean ± SD (7.5 ±1.3, 7.7 ±1.0) mg/dl and (4.6 ±1.4, 4.5 ±1.1) for smokers
and nonsmokers respectively. While alkaline phosphatase reveled significant
increase in smokers group comparer to nonsmokers P-value≤ 0.00 with mean ±
SD (167.3 ± 84.9, 107.9±38.0) for smokers and nonsmokers respectively. This
study revealed positive correlation between age and ALP, phosphate, number of
cigarette per day and duration of smoking correlation coefficient (0.36, 0.095,
0.08, 0.298) respectively. While weak negative correlation found between age
and calcium levels. Duration of smoking showed positive correlation with ALP
and number of cigarette, While weak negative corralled found with calcium and
phosphate levels correlation coefficient (0.198, 0.66, -0.11, -0.30) respectively.
Number of cigarette smoke per day showed positive correlation with ALP,
calcium, phosphate correlation coefficient (0.282 , 0.45) respectively and no
correlation with calcium correlation coefficient(0.00) . positive correlation
assessed with phosphate and ALP, calcium correlation coefficient (0.65, 0.295)
respectively. While weak negative correlation found between calcium levels and
ALP correlation coefficient (-0.15).
Smoking has significantly increase levels of serum alkaline phosphatase . But it
has insignificantly increase or decrease the levels of calcium and phosphate.
