Abstract:
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease
that affects multiple organ systems with immune complexes and a large array of
autoantibodies. Haematological abnormalities are common findings in patients
with SLE with increased risk for thrombosis. The study aimed to evaluate the
risk of thrombosis and haematological changes on women with Systemic lupus
erythematosus.
Materials and Methods: This is an analytical case control study carried out in
Khartoum state in military hospital, in the period from August to December
2017. Thirty women diagnosed with SLE and thirty matched control group were
recruited in this study. EDTA and citrated blood samples were collected from
each patient and control for Complete blood count and D-dimer. Data was
analyzed by SPSS version 20.
Results: The mean of D-dimer in SLE patients was (379ng/ml) and in control
was (89.58ng/ml) that showed significant increased (P value = 0.00) in SLE
patient than control group. Moreover, the highest level of D-dimer (936.5 ng/ml)
was related to the most clinical severity patients with significant association
between severity of disease and D-dimer level (P value= 0.00). The means of
Haemoglobin, Packed cell volume, Total white blood cells, Thrombocyte,
Neutrophil/Lymphocyte ratio for SLE patients were 11.6 g/dl, 36.3%, 5.78 x
109/L, 262 x 109/L, (3.33) respectively, while the means of the same parameters
in the same order for the control were 11.96 g/dl, 35.75%, 5.42x109/L,
288x109/L, (1.61) respectively. No significant differences between patients and
controls in CBC, all P values was (P value > 0.05) except in N/L ratio which was
significantly increased in patients (P value= 0.026). On the other hand, there
were no significant differences in D-dimer level and CBC in between group of
medication and duration of disease, also there were no significant differences in
severity of disease for CBC, all P values (P value > 0.05). Adding to that, there
were no significant differences in D-dimer on the different haematological
situation (P value > 0.05).
Conclusion: The study concluded that, there was a significant increase in the Ddimer
level among women with SLE and it is associated to the clinical severity
of the disease, also there were no significant differences between patients and
control group in CBC.
