Abstract:
This study was conducted in Dr. Salma Center for
hemodialysis in Khartoum from January to June 2010. The
objective of this study is to determine effect of hemodialysis
as risk factor of thrombosis in end stage renal failure
patients. Samples were collected randomly from 50 patients
under haemodialysis.
Blood samples were collected, 2.5 ml in citrate
anticoagulant and analyzed by automated blood coagulation
analyzer for measurement of PT and APTT by seconds and D-
dimer Redder II to measurement D-dimer concentration by
mg/L compared to normal control.
The results showed that
suffering
from
risk
of
14% of the patients were
thrombotic
embolism
with
concentration of D-dimer >0.3mg/L in D dimer and 86%
were normal, 62% of patients under dialysis were male,
while 38% females and the mean age was 43 years old.
Also showed that there was insignificant difference in PT
which
16.1
sec
with
P.value
(0.173),
and
significant
difference in APTT which 73.8 sec with P.value (0.000), D
dimer level was 2.26mg/L with P.value (0.012).
PT, APTT, and D dimer level were increased with
increasing of duration of dialysis, but the difference was
statistically insignificant.
On the other hand increasing age of patients lead to
increase possibility of thrombosis significantly by an increase
of D dimer concentration, but insignificantly in PT and APTT.
Finally there was significant differences in APTT in
patients were treated with recombinant erythropoietin and
iron supplement, but the difference was insignificant for PT,
and D dimer concentration.
