Abstract:
Background: Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycaemia
resulting from defects in insulin secretion, insulin action, or both, and occurs in almost all
populations of the world a variable prevalence.
Objectives: The current study assessed the impact of lycopene on adipokines and
paraoxonase (PON) in stereptozotocin-induced diabetic rabbits.
Materials and Methods: A total of one hundred of rabbits (Albino Rabbits) of both sexes
weighing between 1.5-2.1 kg were completely randomized in four groups (G) comprising 25
rabbits each. Diabetes was induced by a single intraperitoneal injection of streptozotocin (35
mg/kg body weight) feeding on a high fat regimen. Rabbits in G 3,4 which were administered
10 and 20 mg/kg respectively of lycopene for 4 weeks. The serum levels of leptin,
adiponectin, ghrelin, resistin, and tumour necrosis factor – α (TNF-α) were measured by
enzyme-linked immunosorbent assay (ELISA), while serum PON was measured by
spectrophotometric method. SPSS computer software was used for data analysis.
Results:Results showed that lycopene administration at both doses significantly reduced the
leptin, resistin, TNF-α, and glucose levels compared to diabetic control groupG2. Consistent
significant increases (p < 0.05) were noticed in the level of paraoxonase, adiponectin, and
ghrelin in diabetic rabbits dealt with lycopene in comparison with diabetic rabbits of control
group G2.
Conclusions: The high leptin, resistin, and TNF-α levels and oxidative damage whereas low
linked with diabetes, were improved with the administration of lycopene.
