Abstract:
Proton spectroscopy has been recognized as a safe and non-invasive diagnostic method
that coupled with MRI techniques, allows for the correlation of anatomical and
physiological changes in the metabolic and biochemical processes occurring in a
previously determined volume in the brain. The aim of this study was to determine the
role of non-invasive technique MRS in characterization of brain tumors. Brain biopsy is
invasive method, with many complication may happened during the procedure. Patient
needs to be investigated by a noninvasive method with the same accuracy of the biopsy
result . This study was a prospective; descriptive study of 200 patients investigated with
single voxeL MR spectroscopy protocol Following routine MRI, in the period from july
2014 to july 2017 in royal care hospital in Khartoum. The data (annual incidence,
frequencies of BTs based on gender and age, anatomical location, pathologies and
geographical distribution) analyzed using EXCEL software which revealed that: : MRS
showed excellent diagnostic achievement relative to standard (histology) with accuracy
86.8%BTs increase annually by a factor of 7.2% and predominant among male with
57.1%. The involved anatomical brain sites were midbrain 35%, left brain (30%) and
right brain (24%). BTs observed among age groups of 1-10 years old for both gender
with increasing similar trend incidence following aging which peaking at 55-65 years old.
The common pathologies of brain were atrophy and infarction that represents 13.8% and
7.2% respectively and benign and malignant tumors represented (19.8%) and (34.4%)
respectively. The most endemic sectors by BTs were central and Northern of Sudan that
represented 45% and 35% respectively, then eastern and southern of Sudan that
represented 12% and 8% respectively.MRS added to conventional MRI helps in tissue
characterization of intracranial mass lesions, there by leading to an improved diagnosis of focal brain disease.
