Abstract:
This study was conducted in Khartoum state in Military Hospital to compare
creatine kinase (CK) level and thyroid hormones in thyroid dysfunction
patients with healthy individuals.To do this hundred adult Sudanese
individuals
aged
(25male:75female),
(19
as
–
76
study
years)
group
were
(50
participate
with
in
the
hyperthyroidism
study
:
50
hypothyroidism) in addition to fifty with normal thyroid function as control
group .
At P < 0.05 estimated Creatinine Kinase was significantly decrease in
patients with hyperthyroidism and significantly increase in patients with
hypothyroidism compared with the control group (P-value 0.000).The results
were formed to be as follow:
(18±6 U/L) versus (109±38U/L) for hyperthyroidism and (335±119U/L)
versus (109±38U/L) for hypothyroidism.Significant correlation found between
total CK, age and sex in hyperthyroidism and hypothyroidism P-value (0.04,
0.05), (0.04, 0.03) respectively.Also there was Significant correlation
detected between total CK and TSH in hyperthyroidism and hypothyroidism
with p-value (0.05) and (0.003) respectively.
Significant correlation between total CK and T4 & T3 in hyperthyroidism with
p-value less than 0.05 ,p-value is (0.04) for both ,also there was significant
p-value
with
hypothyroidism
in
3T4&T
and
CK
between
correlation(0.04&0.03) respectively. This study demonstrated that hyperthyroidism
decrease total serum CK level ,in contrast hypothyroidism can elevate total
serum CK level .Also the study found that there was positive correlation in
creatine kinase and thyroid stimulating hormone (TSH) and negative
correlation with thyroxine (T4) and tri-iodothyronine (T3). CK level must be
.assessed and screened for patients with thyroid dysfunctions
