Abstract:
This is a hospital based descriptive retrospective study
conducted at Omdurman Military Hospital (Khartoum
state) during the period from March to July 2013, aimed to
detect androgen receptor in prostate cancer.
A total of 40 patients previously diagnosed with prostatic
lesions were selected in this study. Their ages ranged
between 50-88 years old with mean age (66) year. Tissue
sections were stained using two methods; histochemical
method
using
histopathological
method
using
haematoxylin
diagnosis
new
indirect
and
and
eosin
stain
for
immunohistochemical
technique
for
androgen
receptor. The data obtained was analyzed using SPSS
program version 11.5.
Out of 40 patients with prostatic lesions, histopathological
diagnosis revealed 13(32.5%) as prostatic hyperplasia and
27 (67.5%) as adenocarcinoma. Adenocarcinoma showed
10
(37%)
well
differentiated,
13(48%)
moderate
differentiated and 4 (15%) poor differentiated. Depending
on histopathological diagnosis as gold standard the
expressions of AR were found as 2 and 14 in benign
hyperplasia and adenocarcinoma lesions respectively, with
significant relation between AR expression and type of
lesions. This study found no significant relation between
AR expression and age group. High expression common
among well differentiated adenocarcinoma while moderate
and poor differentiated show commonly negative results
with insignificant relation between AR expression and
cancer stages.
The study conclude AR expression help in differentiation
between benign hyperplasia and adenocarcinoma.
