Abstract:
The aim of the study is to compare between C-reactive
protein and LDL cholesterol as markers for cardiovascular
events in Sudanese types 2 diabetes mellitus.
Fifty blood samples were collected from Sudanese
diabetic patients with type 2 diabetes mellitus, their age range
from (35 – 80) years, and fifty healthy volunteers as control
group
for
the
comparison.
Serum
LDL
was
estimated
enzymatically with spectrophotometer (Biosystem 310), and
CRP was measure qualitative by slide methods. We assessed the
value of these two measurements in predicting the risk of cardiovascular events
in the study population.
The study observed significant increase in the LDL
cholesterol level in the study group of type 2 diabetes mellitus
when compared with control group (130.50± 44.4 mg/dl)
verses (77.76±20.96 mg/dl) respectively, (p.value = (0.00).and
the level of LDL is greater in females than in males test group
of type 2 diabetes mellitus (116.42±47.81 mg/dl) verses
(90.71±34.1
mg/dl)
respectively
p.value(0.03).
significant
maximum elevation of LDL was observed during the early
4
period of type 2 diabetes mellitus in group 2 ( more than 10
years) (141.03±48.26 mg/dl) in contrast, the CRP reached the
maximum level in group 1 (1-5 years from the onset of type 2
diabetes mellitus).
These data suggest that the C-reactive protein is higher
in test group of type 2 diabetes mellitus than in healthy
individuals, reached the peak maximum in first five years from
onset of type 2 diabetes mellitus, where LDL cholesterol level
reached the peak maximum after more than 10 years from
onset of type 2 diabetes mellitus.
