Assessment of hyperprolactinemia in infertile women in Khartoum and its correlation with TSH

Abstract

Background:- Infertility is a global health problem with an increasing incidence. In view of the increasing number of infertility among Sudanese women, that has an impact on ovulation and menstruation and other complications . hyperprolactinemia is the most prevalent endocrine disorder in hypothalamic- pituitary axis especially among reproductive age women affecting about one-third of infertile women hyperprolactinemia cause reproduction disorders (infertility), early diagnosis and treatment of these disease are important OBJECTIVE :- To assesst of hyperprolactinemia in infertile women and its correlation with TSH Methods:- analytical, cross- sectional and hospital-based study included Sudanese women who live in Khartoum- State- Sudan, during the period from March 2016 to July 2016.A total of 80 infertile Sudanese women Serum prolactin and TSH levels were estimated using commercially specific Enzyme Linked sorbent immunoassay (ELISA) Results:- Assessment of hyperprolactinemia in infertile women was 25 %.The mean serum prolactin level in hyperprolactinemic females was 35.910μg/L. The assessment of high TSH level in infertile Sudanese women with hyperprolactinemia was (25%) . there is moderate posstive correlation between PRL withTSH (R=0.614 )(p value=0.00) Conclusion: -, There is a high freqquencey of hyperprolactinemia in infertile women. A positive correlation of 1:4 was found between high TSH level and hyperprolactinemia in infertile females emphasizes the importance of estimating both serum prolactin and TSH in infertile women.