Estimation of Complete Blood Count and Platelet Indices In Sudanese patients with Malaria

Abstract

This cross sectional descriptive study was conducted in sudan to identify the values and different hematological parameter in malaria patients this include complete blood count and platelet indices . Ninty five blood sample and fifty control sample are collected 2.5 ml blood from each individual into K2EDTA containers .The final result showed statistically significant difference in the mean hemoglobin and hematocrit level between malaria patient (Hb 13.2g/dl ± 2.1, HCT 39.4 % ± 5.6) and control (Hb14.2±1.8 ,HCT±41.3±4.6), p. value of Hb = 0.005) (P. value of HCT= 0.041) ,and the malaria patients are associated with normocytic normochromic anemia . It showed there was significant differences in platelet count and platelet indices between malaria patient (platelet count 190.7 x 10 9/L ± 102, PDW13.5fl ± 2.4, P.LCR 26.8% ± 6.6) and control (platelet count 269.1 ± 63.7, PDW11.9 ± 1.7, P.LCR 23.7 ± 6.6), ( P .value of platelet count = 0.000 , P .value of PDW = 0.000 ,P. value of P.LCR=0.012). This study also showed difference in mean platelet count and platelet indices according to severity of infection was highly statistically significant according to ANOVA test (platelet count 190.7 x 10 9/L ±102, P .value = 0.000)( PDW 13.5 fl ± 2.4 , P .value = 0.00) (p.lcr 26.8 %± 6.6, P .value= 0.012) but there was no statistical different in MPV(10.0 fl ± 1.2, P .value= 0.296). Also there was no statistical different in WBCS count between malaria patient (6.3 x 10 9/L ± 2.1) and control (6.79±1.9),( P .value = 0.163) and RBCS count between malaria patient (4.9x 10 12/L ± 0.7) and control(9.8 ± 0.6),(P .value = 0.498). The study showed no statistical different in all parameter in comparison with age groups and gender. Finally all this hematological changes enables the clinician to establish an effective and early therapeutic intervention in order to prevent the occurance of major complication .