Detection of Acidic Mucins and Corpora Amylacea in Prostate Tumors

Abstract

This is a retrospective descriptive study conducted at Khartoum state, at Sudan University of science and technology during the period between March and July 2014.This study aimed to detect the expression of acidic mucins and corpora amylacea in tissues affected with prostate cancer and benign prostatic hyperplasia. 39 blocks were collected, 29 (74.4%) of them were prostate cancer and 10 (25.6%) of them were benign prostatic hyperplasia, with age range between 50 and 86. Blocks were cut in 5 µm thickness by rotary microtome. Acidic mucins were identified using alcian blue staining technique while corpora amylacea were identified using haematoxylin and eosin staining technique. Acidic mucins expression were observed in 16 cases of malignant tumor and not observed in13 cases of malignant tumor, and not observed in all cases (10) of benign tumor, with significant association with malignant condition (Pvalue 0.000). The Corpora amylacea expression observed in one case of malignant tumor and not observed in 28 case of malignant tumor, and observed in 7 cases of benign tumor and not observed in 3 cases of benign tumor with significant association with benign condition (Pvalue 0.002). From this resultconcluded thatacidic mucins expression associated with malignant prostate condition. Corporaamylacea appearance is associated with benign condition but their presence not used to exclude malignancy.