Evaluation of some of the haemostatic parameters in diabetic patients attending Jaber Abu Eleaz center and Turkish Teaching Hospital

Abstract

This is an analytical case control study conducted during the period from November 2009 to March 2010, in Jaber Abu Eleaz Specialized Center and Turkish Teaching Hospital. The study population were diabetic patients, the investigation included PT, APTT and INR to evaluate coagulation mechanism among diabetic patients. One hundred samples were collected from diabetic patients of both type1 and type2 with age range 5 to 75 years and disease duration range 1 to 30 years. Twenty control samples were collected from healthy- non diabetic volunteers within the same age groups of the study population.PT and APTT were estimated using Coagulometer. Variable results for PT value were found when compared with mean PT of controls according to age groups and duration of the disease without statistical significant difference and showed slight increased in both type1 and type2 D.M. but also without statistical significant ,and there was positive weakly statistically insignificant correlation between PT and age of the patient(P-value =0.177) and duration of the disease(P-value =0.783) .APTT showed increased values within age where the significant elevation occurred in age above 65 years (66-75 years old) (P-value=0.006) according to the duration of the disease APTT showed elevation directly proportional to the increased duration of the disease where the significance elevation was found to be among duration of more than 25 years (26-30 years duration group) (P-value=0.032), according to type of D.M. APTT increased in both types but in type1 there was a significant elevation (P-value=0.004) ,there were weakly positive statistically insignificant correlation between APTT and age of the patient(P-value =0.545) and there were weakly positive statistically significant correlation between APTT and duration of the disease (P–value=0.023). INR according to age group and duration of the disease showed variable results without significant differences but according to type of D.M. showed slightly increase when compared to mean INR of normal controls in both type1 and type2 D.M. but without statistical significance, there were weakly positive statistically insignificant correlation between INR and age of the patient(P-value=0.504) and duration of the disease(P-value=0.705) .