Preparation, Quality Control & Primary Uses of Some Indium-111 Radiopharmaceuticals

Abstract

Indium-111 is a common radioisotope in Nuclear Medicine; it ranks second radioisotope after 99mTc, and it is used to prepare a number of radiopharmaceuticals for a number of diagnostic applications. Because of non-availability of textbooks or monographs on 111In-radiopharmaceuticals in our University and hospital libraries in Sudan, this research has been conducted as an attempt to avail a comprehensive review containing the relevant and most needed knowledge that related to the usage of 111In in Nuclear Medicine from Internet and Journals in the field of NM and pharmacy. Currently, 111In is yet to be introduced in our centers in Sudan as an indicator nuclide. However, there is a great need for using this important radioisotope. This study presents a comprehensive coverage on indium chemistry, physical properties, production and decay, as well as preparation, quality control procedures, administration, pharmacokinetics (biodistribution, mechanism of localization and clearance routes), indications, contraindications, side effects and radiation dosimetry of indium radiopharmaceuticals; namely Indium-111 chloride, 111In-pentetate (DTPA), 111In-oxyquinoline (oxine), 111In-capromab pendetide (ProstaScint), 111In- Imciromab pentetate (Myoscint), 111In-Pentetreotide (Octreoscan) and 111In -Satumomab pendetide (OncoScint).