Measurement of the Serum Levels of Cardiac Enzymes among Sudanese with Type 2 Diabetes Mellitus in Reference to their Body Mass Index

Abstract

This is a cross-sectional study conducted during the period from March to August 2010, to asses the serum levels of cardiac enzymes (Creatine kinase, aspartate aminotransferase and lactate dehydrogenase) in 70 Sudanese patients with type 2 diabetes mellitus in reference to their body mass index (38 obese and 32 non-obese) as a study group compared with 30 apparently healthy subjects (non-diabetic, non-obese) as a control group. Participants in this study were from different hospitals and health centers in Khartoum state, Sudan. Age and gender of the study group were matched with the control group. The serum levels of cardiac markers: CK, AST and LDH were measured using BTS 305 spectrophotometer and commercial kits from .Biosystem Company The mean of the serum levels of total Creatinine kinase of the diabetic and diabetic obese groups were significantly raised (P. value= 0.043) and (P=0.021), respectively, whereas, they were insignificantly changed in .diabetic non-obese group when compared to that of the control group The mean of the serum levels of Aspartate aminotransferase level of all diabetic group were insignificantly changed when compared to that of the .(control group (P= 0.141 The mean of serum levels of lactate dehydrogenase of the diabetic and diabetic obese groups were significantly raised (P=0.045) and (P=0.029), respectively, whereas, they were insignificantly changed in diabetic non- .(obese group when compared to that of the control group (P=0.180 In the diabetic group the serum levels of Creatine kinase, Aspartate transferase and lactate dehydrogenase levels showed insignificant weak positive correlation with both, the duration of the diabetes mellitus and the .body mass index of the patients