Determination of Some Laboratory findings in Sudanese hemophiliacs patients in Khartoum July 2012

Abstract

This is a descriptive cross sectional study which was conducted during the period from June to July 2012 aimed to determine some laboratory findings among Sudanese hemophiliacs. A total number of 40 males hemophiliac patients were consecutively recruited. The aim of this study is to assess the Activated partial thromboplastin time (APTT), Factor VIII and IX assay, Prothrombin time (PT) and Platelets count. The age range is from 3 to 28 years, with the mean of 15.5±12.5. Hemophilia A patients were 37/40 (92.5%), while hemophilia B patients were 3/40 (7.5%). The mean value of Activated partial thromboplastin time (APTT) of included patients was 115 ±55 seconds, (average 60 – 210 seconds), this was significantly longer than that of controls (p=0.0001). Patients with mild hemophilia had FVIII level that ranged from 5-25% were 27% of hemophilia A patients, those with moderate hemophilia had factor VIII level ranged from 1-5% were 73%of hemophilia A patients. No patient found with severe type of hemophilia. The prothrombin time (PT) of hemophilic patient's samples was 13.8±7.1 seconds, (average 10.9 – 12.0 seconds) compared to 12.2±3 seconds of normal control (p=0.09). The mean platelets count was 230±18 X103 /μL and range (175 – 280 X 103 /μL). No HIV tests or other hepatitis viruses screening were done.