The Evaluation of Plasma Transaminaes, Total Protein and Albumin as Indicators of Severity of Pre-eclampsia

Abstract

The value of transaminases, total protein and albumin as indicator of severity of pre-eclampsia among Sudanese patients was studied in the period 1st May to end of October 2oo6. It was crosssectional test and control study. The Study was carried out as a multi center study in Khartoum state in different maternity units, including, Khartoum Teatching Hospital and Omdruman maternity Hospital. Information were collected from the patients by taking history through a questionnaire .laboratory examination and analysis of plasma transaminases, total protein and albumin were done. Urine was test for protein. A total of 50 patients admitted with pre-eclampsia were compared with 30 ladies with normal pregnancy, both were selected at third trimester of pregnancy. Most of the patients were primgravida in the age group between 18 to 39 years. The control groups match the test group. The result obtained for both groups were statistically analyzed using T test correlation. The average value of plasma ALT among the control group was.11.03u /L compared to 47.74u/l in those patients admitted as cases of pre- eclampsia and the average value of plasma AST among the control group was10.166U /L compared to 42.66u/L in those patient admitted as cases of pre eclampsia. The average value of plasma Total protein among the control group was 72.56g /L compared to 52.04g/L in those patient admitted as cases of pre eclampsia , the average value of plasma albumin among the control group was43.26g /L compared to 30.2g/L in those patients admitted as cases of pre- eclampsia . The results obtained showed that there were significance difference between plasma transaminases,total protein and albumin in control groups and test groups (p<0.05). In conclusion , the study confirms that the value of plasma transaminase, total protein and albumin have good correlation with severity of pre-eclampsia.