Serum Cholestrol Level in Sudanes Renal Transplant Recipients

Abstract

A prospective study conducted during the period . July 2004 to April 2005 , 65 people was examined for serum cholesterol level ( 45 Renal transplant recipients patients versus, 25 control group ) The renal transplant recipients all of them under follow up at Dr. Salma center for kidney dialysis and transplant. A sample of blood from each was taken , the specimens were analyzed for serum cholesterol and whole blood cyclosporine concentration for study group , while only serum cholesterol level for control group , The results obtained shows that there was significant difference between the serum cholesterol in study group and control group . (204+38.21 to 155.4+15.68, p<.000 ) The study group divided into three sub groups according to duration post renal transplantation ( subgroup (A), < 12 months ) ,( subgroup (B) 12 - 24 months ) , ( subgroup (C) >25 months ). Statistically significant negative correlation was seen between duration after renal transplantation and serum cholesterol level To study the correlation between the cyclosporine concentration and serum cholesterol level patients group divided into three subgroups according to cyclosporine concentration (subgroup (L) <150 ng/ml ) subgroup (M) 150 - 225 ng/ml ), (subgroup(H)>226 ng/ml ) . The results obtained and statistically shows no significant correlation between cyclosporine concentration and serum cholesterol level . The finding of this study shows that serum cholesterol is maximal in the first year post renal transplantation (subgroup(A) ) and decreased gradually through the duration post renal transplantation , but still higher than that in control group .‫‪A person with serum cholesterol level(240 mg/dl and‬‬ ‫‪above ) has more than twice the risk of heart disease than the‬‬ ‫‪others below (240 mg/dl ). In this study 17.5% of patients have‬‬ ‫. ‪serum cholesterol >240 mg/dl , and 82.5% below 240mg/dl‬‬